NCBI Summary:
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]
General function
Nucleic acid binding, DNA binding, Transcription factor
Species: mouse
Mutation name: type: None fertility: None Comment: In Hmga1-deficient mice, Foti et al. (2005) observed decreased insulin receptor expression in muscle, fat, and liver, largely impaired insulin signaling, and severely reduced insulin secretion, causing a phenotype characteristic of human type 2 diabetes.