| NAD(P)H dehydrogenase, quinone 1 | OKDB#: 3363 |
| Symbols: | NQO1 | Species: | human | ||
| Synonyms: | DTD, QR1, DHQU, DIA4, NMOR1, NMORI,DTD, QR1, DHQU, DIA4, NMOR1, NMORI,NAD(P)H:MENADIONE OXIDOREDUCTASE 1, DIOXIN-INDUCIBLE 1, NMOR1|DIAPHORASE 4, DIA4 | Locus: | 16q22.1 in Homo sapiens |
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| General Comment | NCBI Summary: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | ||||
| General function | Enzyme, Oxidoreductase | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | Oogenesis, Oocyte maturation | ||||
| Comment | decreases during oocyte developemnt | ||||
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| Ovarian localization | Oocyte | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | July 18, 2006, 11:29 a.m. | by: |
alex email:
home page: |
| last update: | Nov. 22, 2013, 9:37 a.m. | by: | hsueh email: |
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