| Cancer/testis Antigen 1b | OKDB#: 341 |
| Symbols: | CTAG1B | Species: | human | ||
| Synonyms: | CTAG, ESO1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1,CANCER/TESTIS ANTIGEN 1, CTAG1|CTAG|NEW YORK ESOPHAGEAL SQUAMOUS CELL CARCINOMA 1, NYESO1|LAGE2|LAGE2B | Locus: | Xq28 in Homo sapiens |
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| General Comment |
By serologic analysis of recombinant cDNA expression libraries of an esophageal carcinoma cDNA library, Chen et al. (1997)dentified a clone corresponding to the CTAG (cancer/testis antigen) gene, which they designated NYESO1. Northern blot analysis of normal human tissues revealed expression of an 0.8-kb mRNA in testis and ovary. RT-PCR analysis showed expression in a wide array of human cancers. The CTAG gene encodes a 180-amino acid polypeptide with one putative transmembrane domain. Chen et al. (1997) isolated genomic clones of the CTAG gene. The gene consists of 3 exons spanning 8 kb. By somatic cell hybrid mapping and by fluorescence in situ hybridization, Chen et al. (1997) mapped the CTAG gene to chromosome Xq28. The authors noted that a number of cancer/testis (CT) antigens have also been mapped to the X chromosome, including members of the MAGE family.
NCBI Summary: Cancer-testis antigen |
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| Comment | Serological analysis of recombinant cDNA expression libraries (SEREX) using tumor mRNA and autologous patient serum provides a powerful approach to identify immunogenic tumor antigens. In a case of esophageal squamous cell carcinoma several candidate tumor targets were identified. One of these, NY-ESO-1, showed restricted mRNA expression in normal tissues, with high-level mRNA expression found only in testis and ovary tissues. Reverse transcription-PCR analysis showed NY-ESO-1 mRNA expression in a variable proportion of a wide array of human cancers, including melanoma, breast cancer, bladder cancer, prostate cancer, and hepatocellular carcinoma. NY-ESO-1 encodes a putative protein of Mr 17,995 having no homology with any known protein. The pattern of NY-ESO-1 expression indicates that it belongs to an expanding family of immunogenic testicular antigens that are aberrantly expressed in human cancers in a lineage-nonspecific fashion. These antigens, initially detected by either cytotoxic T cells (MAGE, BAGE, GAGE-1) or antibodies [HOM-MEL-40(SSX2), NY-ESO-1], represent a pool of antigenic targets for cancer vaccination. | ||||
| Cellular localization | Cytoplasmic | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Dec. 11, 1999, midnight | by: |
De email:
home page: |
| last update: | Aug. 10, 2006, 10:22 a.m. | by: | Alex email: |
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