| ISLR | OKDB#: 346 |
| Symbols: | ISLR | Species: | human | ||
| Synonyms: | Immunoglobulin superfamily containing leucine-rich repeat | Locus: | 15q23-q24 in Homo sapiens |
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| General Comment |
Nagasawa et al. (1997)isolated a cDNA for a novel human protein containing both a leucine-rich repeat (LRR) and an immunoglobulin (Ig)-like domain. This gene was referred to as ISLR for 'immunoglobulin superfamily containing LRR.' The predicted protein comprises 428 amino acids and contains a hydrophobic N-terminal 18-amino acid putative signal
peptide. On Northern blot analysis, the authors found a 2.4-kb ISLR transcript in various human tissues, including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach, and spinal cord, as well as fetal lung and fetal kidney.
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| General function | Cell adhesion molecule | ||||
| Comment | Despite the variety of their functions, all members of the Ig superfamily are involved in adhesion or binding to other proteins in solution or at the cell surface. Therefore it is possible that the ISLR protein may also interact with other proteins or cells. | ||||
| Cellular localization | Cytoplasmic | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Dec. 13, 1999, midnight | by: |
De email:
home page: |
| last update: | Aug. 10, 2006, 10:49 a.m. | by: | Alex email: |
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