| UDP glucuronosyltransferase 2 family, polypeptide B35 | OKDB#: 3622 |
| Symbols: | Ugt2b35 | Species: | human | ||
| Synonyms: | C730031G17 | Locus: | 5 in Homo sapiens |
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| General Comment | ||||
| General function | Enzyme | |||
| Comment | ||||
| Cellular localization | ||||
| Comment | ||||
| Ovarian function | Ovulation | |||
| Comment | Regulation of uridine diphosphate-glucuronosyltransferase 2B15 expression during ovulation in the rat. Dam PTM et al. (2017) Uridine diphosphate-glucuronosyltransferase 2B15 (UGT2B15) conjugates 5α-androstane-3α, 17β-diol (3α-diol) to 3α-diol glucuronide (3α-diol G) in steroid target tissues. The present study investigated the regulation of UGT2B15 expression during the ovulatory process in the rat. Real-time PCR analysis revealed that treatment of immature rats with equine chorionic gonadotropin followed by human chorionic gonadotropin transiently stimulated UGT2B15 gene expression in granulosa cells of preovulatory follicles within 6 h. The progesterone receptor antagonist RU486 suppressed the gonadotropin-induced UGT2B15 expression. The expression of UGT2B15 and the levels of 3α-diol G were transiently increased by luteinizing hormone (LH) treatment in cultured preovulatory follicles. The LH-stimulated UGT2B15 mRNA level in cultured preovulatory follicles was inhibited by inhibitors of adenylyl cyclase, phosphoinositide 3-kinase and mitogen-activated protein kinase. Furthermore, a vitamin D receptor agonist (calcitriol) suppressed the LH-stimulated UGT2B15 expression in a dose-dependent manner. Taken together, these results indicate that gonadotropins transiently stimulate UGT2B15 expression and activity in preovulatory follicles, and UGT2B15 mRNA levels are regulated by the progesterone receptor and vitamin D receptor.////////////////// | |||
| Expression regulated by | LH | |||
| Comment | ||||
| Ovarian localization | Granulosa | |||
| Comment | Tissue- and Gender-Specific mRNA Expression of UDP-Glucuronosyltransferases (UGTs) in Mice. Buckley DB et al. UDP-glucuronosyltransferases (UGTs) catalyze phase-II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. Currently, little information regarding tissue or gender-specific expression of mouse UGTs is available. Mice are increasingly popular models in biomedical research, and therefore, thorough characterization of murine drug metabolism is desired. The purpose of the present study was to determine both tissue- and gender-specific UGT-gene-expression profiles in mice. RNA from fourteen tissues was isolated from male and female C57BL/6 mice and UGT expression was determined by the bDNA assay. Ugts highly expressed in mouse liver include Ugt1a1, Ugt1a5, Ugt1a6, Ugt1a9, Ugt2a3, Ugt2b1, Ugt2b5/37/38, Ugt2b34, Ugt2b35, and Ugt2b36. Several isoforms were expressed in the GI tract, including Ugt1a6, Ugt1a7c, Ugt2a3, Ugt2b34, and Ugt2b35. In kidney, Ugt1a2, Ugt1a7c, Ugt2b5/37/38, Ugt2b35, and Ugt3a1/2 were expressed. Ugt expression was also observed in other tissues: lung, Ugt1a6; brain, Ugt2b35; testis and ovary, Ugt1a6 and Ugt2b35; and nasal epithelia, Ugt2a1/2. Male-predominant expression was observed for Ugt2b1 in liver, Ugt2b5/37/38 in kidney, and Ugt1a6 in lung. Female-predominant expression was observed for Ugt1a1 and Ugt1a5 in liver, Ugt1a2 in kidney, Ugt2b35 in brain, and Ugt2a1/2 in nasal epithelia. UDP-glucose pyrophosphorylase was highly expressed in liver, kidney, and GI tract, whereas UDP-glucose dehydrogenase was highly expressed in the GI tract. In conclusion, marked differences in tissue- and gender-specific expression patterns of Ugts exist in mice, potentially influencing drug metabolism and pharmacokinetics. | |||
| Follicle stages | Preovulatory | |||
| Comment | ||||
| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
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| created: | Oct. 25, 2006, 6:44 a.m. | by: |
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| last update: | May 2, 2017, 10:53 a.m. | by: | hsueh email: |
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