| Minichromosome Maintenance, S. Cerevisiae, Homolog Of, 4 | OKDB#: 3647 |
| Symbols: | MCM4 | Species: | human | ||
| Synonyms: | CDC21, CDC54, hCdc21, MGC33310, P1-CDC21,CELL DIVISION CYCLE 21, S. POMBE, HOMOLOG OF|CDC21, S. POMBE, HOMOLOG OF | Locus: | 8q11.2 in Homo sapiens |
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| General Comment | NCBI Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. | ||||
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| Cellular localization | Nuclear | ||||
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| Ovarian localization | Oocyte | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Nov. 1, 2006, 4:50 p.m. | by: |
amazinmazin email:
home page: |
| last update: | Nov. 1, 2006, 4:50 p.m. | by: | amazinmazin email: |
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