| Paternally Expressed Gene 10 | OKDB#: 3670 |
| Symbols: | PEG10 | Species: | human | ||
| Synonyms: | Edr, HB-1, Mar2, MEF3L, Mart2, RGAG3, KIAA1051,KIAA1051|EMBRYONAL CARCINOMA DIFFERENTIATION-REGULATED GENE, EDR | Locus: | 7q21 in Homo sapiens |
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| General Comment | NCBI Summary: This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas. | ||||
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| Comment | Imprinted status of pleiomorphic adenoma gene-like I and paternal expression gene 10 genes in pigs. Zhang FW et al. Genomic imprinting is theorized to exist in all placental mammals and some marsupials. Imprinted genes play important roles in the regulation of fetal growth, development and postnatal behavior, but the study of imprinted genes has been limited in livestock. In this study, the polymorphism-based approach was used to detect expression patterns of porcine pleiomorphic adenoma gene-like I (PLAGL1) and paternal expression gene 10 (PEG10) genes. Single nucleotide polymorphisms in exons were detected between the Meishan and Large White breeds in the PLAGL1 and PEG10 genes. The polymorphisms were used to determine the monoallelic or biallelic expression with reverse transcriptase-PCR-RFLP in 44 tissues from 4 heterozygous pigs (based on SNP). Imprinting analysis indicated that the PLAGL1 and PEG10 genes were both paternally expressed in all tested tissues (heart, liver, spleen, lung, kidney, stomach, small intestine, skeletal muscle, fat, uterus and ovary). Our study showed that the method of identifying polymorphic transcripts with reverse transcriptase-PCR-RFLP may be beneficial for detecting the imprinting status of some candidate imprinted genes. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Jan. 3, 2007, 3:51 p.m. | by: |
hsueh email:
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| last update: | Jan. 3, 2007, 3:51 p.m. | by: | hsueh email: |
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