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DNA segment, Chr 19, Wayne State University 12, expressed OKDB#: 3683
 Symbols: D19Wsu12e Species: mouse
 Synonyms: Fxna, MGC28180, mKIAA1815, D19Ertd410e,  Locus: 19 24.5 cM in Homo sapiens


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General Comment
General function Enzyme
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Follicle development, Initiation of primordial follicle growth
Comment Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis. Garcia-Rudaz C et al. In rodents, the formation of ovarian follicles occurs after birth. In recent years, several factors required for follicular assembly and the growth of the newly formed follicles have been identified. We now describe a novel gene, Fxna, identified by differential display in the neonatal rat ovary. Fxna encodes an mRNA of 5.4 kb, and a protein of 898 amino acids. Fxna is a transmembrane metallopeptidase from family M28, localized to the endoplasmic reticulum. In the ovary, Fxna mRNA is expressed in granulosa cells; its abundance is maximal 48 hours after birth, i.e. during the initiation of follicular assembly. Reducing Fxna mRNA levels via lentiviral-mediated delivery of short hairpin RNAs to neonatal ovaries resulted in substantial loss of primordial, primary and secondary follicles, and structural disorganization of the ovary, with many abnormal follicles containing more than one oocyte and clusters of somatic cells not associated with any oocytes. These abnormalities were not attributable to either increased apoptosis or decreased proliferation of granulosa cells. The results indicate that Fxna is required for the organization of somatic cells and oocytes into discrete follicular structures. As an endoplasmic reticulum-bound peptidase, Fxna may facilitate follicular organization by processing precursor proteins required for intraovarian cell-to-cell communication.
Expression regulated by
Comment
Ovarian localization Granulosa
Comment
Follicle stages Primordial, Primary
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Feb. 7, 2007, 1:17 p.m. by: hsueh   email:
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last update: Feb. 7, 2007, 1:20 p.m. by: hsueh    email:



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