Steroid dependent alternative splicing mechanism produces progesterone-dependent (alpha) isoform and truncated, estrogen-dependent (beta) isoform
Hayward-lester et al (1996) Mol Endocrinol 10:1335-1349
General function
DNA binding, Transcription factor
Comment
Cellular localization
Nuclear
Comment
Ovarian function
Follicle development
Comment
Expressed in presumptive granulosa cells of embryonic and neonatal ovaries before follicle organization.
Rendon et al. (2000) Biol Reprod 63, 156-164.
Expression regulated by
Steroids, prolactin
Comment
regulated by progesterone via an overlaping progesterone receptor half-site overlapping a Y-box in the proximal promoter (-162/+90)
Hewetson & Chilton (2003) JBC 278:40177-40185
Ovarian localization
Granulosa, Theca
Comment
Abundant message was detected in granulosa and theca cells surrounding preantral follicles of prepubertal and adult ovaries.
Expression remained high in granulosa cells of antral follicles in mature ovaries but was negligible in late-stage atretic follicles and corpora lutea.