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HPMR

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G protein-coupled receptor 149 OKDB#: 3720
 Symbols: GPR149 Species: human
 Synonyms: IEDA, PGR10,  Locus: 3q25.2 in Homo sapiens
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General Comment
General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Ovulation
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment Edson et al found this gene to be highly expressed in the oocyte (SSR Abstract 74, 2007).
Follicle stages
Comment
Phenotypes
Mutations 1 mutations

Species: mouse
Mutation name: None
type: null mutation
fertility: fertile
Comment: Deletion of the Novel Oocyte-Enriched Gene, Gpr149, Leads to Increased Fertility in Mice. Edson MA et al. Through in silico subtraction and microarray analysis, we identified mouse Gpr149, a novel, oocyte-enriched transcript that encodes a predicted orphan G-protein-coupled receptor (GPR). Phylogenetic analysis of GPR149 from fish to mammals suggests that it is widely conserved in vertebrates. By multitissue RT-PCR analysis, we found that Gpr149 is highly expressed in the ovary and also in the brain and the digestive tract at low levels. Gpr149 levels are low in newborn ovaries but increase throughout folliculogenesis. In the ovary, we found that granulosa cells did not express Gpr149, whereas germinal vesicle and meiosis II stage oocytes showed high levels of Gpr149 expression. After fertilization, Gpr149 expression declined, becoming undetectable by the two-cell stage. To study the function of GPR149 in oocyte growth and maturation, we generated Gpr149 null mice. Surprisingly, Gpr149 null mice are viable and have normal folliculogenesis, but demonstrate increased fertility, enhanced ovulation, increased oocyte Gdf9 mRNA levels, and increased levels of FSH receptor and cyclin D2 mRNA levels in granulosa cells. Thus, Gpr149 null mice are one of the few models with enhanced fertility, and GPR149 could be a target for small molecules to enhance fertility in the assisted reproductive technology clinic.

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created: Oct. 3, 2007, 12:42 p.m. by: hsueh   email:
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last update: Nov. 11, 2009, 11:53 a.m. by: hsueh    email:



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