| Glypican 3 | OKDB#: 3782 |
| Symbols: | GPC3 | Species: | human | ||
| Synonyms: | SGB, DGSX, SDYS, SGBS, OCI-5, SGBS1, | Locus: | Xq26.1 in Homo sapiens |
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| General Comment | NCBI Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome. | ||||
| General function | |||||
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| Cellular localization | Plasma membrane | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | Ovarian tumor | ||||
| Comment | Glypican-3 immunohistochemistry in the ovary. Histopathology. 2008 May 6;. [Epub ahead of print] PMID: 18462363 PMID: 20972242 | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | May 14, 2008, 1:08 p.m. | by: |
hsueh email:
home page: |
| last update: | Oct. 27, 2010, 9:38 a.m. | by: | hsueh email: |
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