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Reproductive homeobox 13 OKDB#: 3809
 Symbols: Rhox13 Species: human
 Synonyms: 1700123J19Rik,  Locus: X A3.3 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: Entrez Gene
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General Comment
General function Nucleic acid binding, DNA binding, Transcription factor
Comment
Cellular localization Nuclear
Comment
Ovarian function Germ cell development
Comment Rhox13 Is Translated in Premeiotic Germ Cells in Male and Female Mice and Is Regulated by NANOS2 in the Male. Geyer CB et al. Male and female germ cells enter meiosis in response to an extrinsic cue by retinoic acid (RA), but the pathways downstream of RA signaling that regulate early gametogenesis remain uncertain. We identified a novel reproductive homeobox gene, Rhox13, transcribed in the prenatal ovary and testis beginning on Embryonic Day (E) 13.5. Translation of RHOX13 also begins in female germ cells on E13.5, but is suppressed in male germ cells until Postnatal Day (P) 3. Translation of RHOX13 coincides with initiation of RA signaling in both male and female gonads in vivo, but occurs precociously in neonatal testes exposed to RA in vitro or in fetal male germ cells when NANOS2 is absent in vivo. Conversely, RHOX13 translation in female germ cells is suppressed in the presence of ectopically induced NANOS2. These results strongly suggest that RHOX13 expression is regulated at a post-transcriptional step by direct interaction of NANOS2 with Rhox13 mRNA to suppress translation. Identification and characterization of Rhox13, a novel X-linked mouse homeobox gene testis, ovary, spermatogenesis, transcription, X chromosome. Geyer CB et al. Homeobox genes encode transcription factors whose expression organizes programs of development. A number of homeobox genes expressed in reproductive tissues have been identified recently, including a colinear cluster on the X chromosome in mice. This has led to an increased interest in understanding the role(s) of homeobox genes in regulating development of reproductive tissues including the testis, ovary, and placenta. Here we report the identification and characterization of a novel homeobox gene of the paired-like class on the X chromosome distal to the reproductive homeobox (Rhox) cluster in mice. Transcripts are found in the testis and ovary as early as 13.5 days post coitum (dpc). Transcription ceases in the ovary by 3 days post partum (dpp), but continues in the testis through adulthood. The Rhox13 gene encodes a 25.3 kDa protein expressed in the adult testis in germ cells at the basal aspect of the seminiferous epithelium.
Expression regulated by
Comment
Ovarian localization Primordial Germ Cell
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Aug. 6, 2008, 11:19 a.m. by: hsueh   email:
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last update: Dec. 30, 2011, 9:40 a.m. by: hsueh    email:



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