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Ovarian Kaleidoscope Database (OKdb)

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glyoxalase I OKDB#: 3852
 Symbols: GLO1 Species: human
 Synonyms: GLYI, GLOD1, HEL-S-74,  Locus: 6p21.3-p21.1 in Homo sapiens


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General Comment NCBI Summary: The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
General function Enzyme
Comment
Cellular localization Secreted
Comment
Ovarian function
Comment Identification of differentially expressed proteins in the ovaries of menopausal women. Zhang LQ 2014 et al. PURPOSE This study investigated proteins differentially expressed in the ovaries of menopausal women in comparison to childbearing women. METHODS Differential protein expression was screened by difference gel electrophoresis and 2-D SDS-PAGE. Four differentially expressed proteins were excised manually, identified by mass spectrometry and confirmed by immunoblot and immunohistochemistry. RESULTS The four proteins were identified as serum amyloid P, heat shock protein 27, Glyoxalase I and Ubiquitin carboxy-terminal hydrolase. Serum amyloid P expression was significantly up-regulated in the ovaries of menopausal women by immunoblot analysis (p<0.05), Glyoxalase I and Ubiquitin carboxy-terminal hydrolase displayed an altered expression pattern, with higher expression in the atretic follicles of menopausal women. Weak Glyoxalase I and Ubiquitin carboxy-terminal hydrolase were observed in the granulosa and theca cells of the follicles of childbearing women. Heat shock protein 27 and serum amyloid P were clearly observed in the atretic follicles of menopausal women, while their expression was restricted to the theca cells and cytoplasm of primordial follicles in the ovaries of childbearing women. All four proteins were predominantly expressed in the atretic follicles of menopausal women. CONCLUSIONS These data suggest that the identified proteins may play a role in the regulation of follicle atresia in menopausal women, although their functions and mechanism warrant further investigation. /////////////////////////
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Dec. 25, 2008, 2:05 a.m. by: hsuehlab   email:
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last update: July 22, 2014, 10:19 a.m. by: hsueh    email:



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