| Suppressor Of Tumorigenicity 7 | OKDB#: 3879 |
| Symbols: | ST7 | Species: | human | ||
| Synonyms: | HELG, RAY1, SEN4, TSG7, ETS7q, FAM4A, FAM4A1, DKFZp762O2113,TSG7|RAY1|FAM4A1 | Locus: | 7q31.1-q31.3 in Homo sapiens |
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| General Comment | NCBI Summary: The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq] | ||||
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| Ovarian localization | Oocyte | ||||
| Comment | Allegro: Analyzing expression and sequence in concert to discover regulatory programs. Halperin Y et al. A major goal of system biology is the characterization of transcription factors and microRNAs (miRNAs) and the transcriptional programs they regulate. We present Allegro, a method for de-novo discovery of cis-regulatory transcriptional programs through joint analysis of genome-wide expression data and promoter or 3' UTR sequences. The algorithm uses a novel log-likelihood-based, non-parametric model to describe the expression pattern shared by a group of co-regulated genes. We show that Allegro is more accurate and sensitive than existing techniques, and can simultaneously analyze multiple expression datasets with more than 100 conditions. We apply Allegro on datasets from several species and report on the transcriptional modules it uncovers. Our analysis reveals a novel motif over-represented in the promoters of genes highly expressed in murine oocytes. The present gene id highly expressed in the oocyte and has a unique promoter motif. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Jan. 25, 2009, 11:21 a.m. | by: |
hsueh email:
home page: |
| last update: | Jan. 25, 2009, 11:21 a.m. | by: | hsueh email: |
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