Pennica D et al reported that cardiotrophin-1 (CT-1) is a new member of the interleukin-6 cytokine family, including leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM),interleukin 6 (IL6), and interleukin 11 (IL11). It was identified from a mouse embryoid body cDNA library by expression cloning. Mouse CT-1 induces features of hypertrophy in neonatal rat cardiac myocytes and
binds to and activates the leukaemia inhibitory factor/gp130 receptor complex. Human CT-1 produced by transfection of the cDNA clones into mammalian cells induces the hypertrophy of neonatal rat cardiac myocytes. Human and mouse CT-1 bind to the leukaemia inhibitory factor receptor on both human and mouse cell lines indicating a lack of species specificity. No binding to the human oncostatin M specific
receptor was detected.
NCBI Summary:
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
General function
Ligand, Cytokine
Comment
Cardiotrophin-1 as a new metabolic biomarker in women with PCOS. Anik Ilhan G et al. (2018) The objective of this study was to investigate cardiotrophin-1 (CT-1) levels as a new metabolic biomarker in women with polycystic ovary syndrome (PCOS). One hundred consecutive women with PCOS were divided into two groups according to presence of metabolic syndrome as MetS+ and MetS-. Clinical, hormonal and metabolic parameters in addition to CT-1 levels were compared between the groups. Correlation analyses were performed between CT-1 and clinical and metabolic parameters in women with PCOS. One hundred PCOS subjects were enrolled in the study, of which 29 subjects were diagnosed with metabolic syndrome. WHR, systolic and diastolic blood pressures, triglyceride, total cholesterol, HOMA-IR, FAI, FGS and CT-1 levels were significantly higher in the MetS+ group compared with the MetS- group. HDL cholesterol was significantly higher in the MetS- group than the MetS+ one. CT-1 levels were found to be positively correlated with diastolic blood pressure, TG levels and FGS. Cardiotrophin-1 may be a promising new metabolic biomarker in women with PCOS. CT-1 may be beneficial for estimating the risk of long-term adverse health consequences and establishing early intervention and preventation strategies.//////////////////
Cellular localization
Secreted
Comment
Ovarian function
Comment
Pennica D et al reported that a 1.7 kb CT-1 mRNA is expressed in adult human heart, skeletal muscle, ovary, colon, prostate and
testis and in fetal kidney and lung.
Expression regulated by
Comment
Ovarian localization
Comment
This gene was found in rat and bovine ovarian cDNA libraries (Unigene).