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Ovarian Kaleidoscope Database (OKdb)

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HPMR

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lysosomal protein transmembrane 4 alpha OKDB#: 3987
 Symbols: LAPTM4A Species: human
 Synonyms: MBNT, Mtrp, LAPTM4, HUMORF13, KIAA0108,  Locus: 2p24.1 in Homo sapiens


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link to BioGPS
General Comment NCBI Summary: This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq]
General function Channel/transport protein
Comment
Cellular localization Other Membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Granulosa
Comment Analysis of gene expression in granulosa cells of ovine antral growing follicles using suppression-subtractive hybridization. Chen AQ et al. Follicular growth, development and ovulation are highly ordered processes that involve the expression of many genes under precise temporal and spatial regulation. However, information on stage-specific gene expression during the antral follicle phase in sheep is not well understood. In the present study, suppression-subtractive hybridization (SSH) was performed to screen genes that were differentially expressed in the granulosa cells between large follicles (LF, >5mm) and small follicles (SF, 3-5mm), and subtractive cDNA library was constructed. Furthermore, with dot-blot analysis, a total of 90 clones randomly selected from the library were proven to be differentially expressed in the granulosa cells. Among these, 38 exhibited high homology to known genes, 14 sequences were corresponding to novel expressed sequence tags (ESTs). Four ESTs, LAPTM4A, SERPINE2, GSTA1, and INHBA, were further examined the reproducibility of the SSH data by the real-time quantitative PCR. Results confirmed an increase expression of respective mRNA in granulosa cells of large follicles compared with that of small follicles. It is concluded that we have identified several genes (known or unknown) that may effect follicular growth, dominance or ovulation in ewes.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Feb. 18, 2009, 12:08 p.m. by: hsueh   email:
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last update: Feb. 18, 2009, 12:09 p.m. by: hsueh    email:



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