| Plakophilin 1 | OKDB#: 399 |
| Symbols: | Plakophilin 1 | Species: | human | ||
| Synonyms: | PKP1 | Locus: | 1q32 in Homo sapiens |
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| General Comment |
Desmosomes represent a special type of the plaque-bearing adhering junctions, characteristic of certain pathways of cell
differentiation, which compositionally are not identical in the various kinds of desmosome-forming cells. While all
desmosomes contain the cytoplasmic plaque proteins desmoplakin I and plakoglobin, they can vary in their specific
complement of desmosomal cadherins and by the presence of additional plaque proteins. Heid, H. W. et al raised monoclonal
antibodies recognizing one such 'accessory' plaque protein, the cytokeratin-binding, basic protein plakophilin 1, originally
introduced as 'band 6 protein' or 'polypeptide D6', which is an abundant desmosomal component in certain epithelia. Using
such antibodies, cDNA clones encoding the bovine and the human protein were cloned. Sequence analyses have revealed the presence of 9.2 repeated units of the arm-motif sequence, confirming that this protein is a member of a larger family of proteins including, inter alia, several membrane-associated plaque proteins such as vertebrate plakoglobin and beta-catenin
as well as the product of the armadillo gene of Drosophila.
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| General function | Cytoskeleton | ||||
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| Cellular localization | Secreted | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | Oocyte | ||||
| Comment | Brevini-Gandolfi TA et al reported that the length of the poly(A) tail of plakophilin, was determined at the germinal vesicle (GV) and metaphase II (MII) stage. The results indicated that the poly(A) tail of this gene is shorter after in vitro maturation. | ||||
| Follicle stages | Antral | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Jan. 24, 2000, midnight | by: |
hsueh email:
home page: |
| last update: | Jan. 24, 2000, midnight | by: | hsueh email: |
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