| Atp Citrate Lyase | OKDB#: 4013 |
| Symbols: | ACLY | Species: | human | ||
| Synonyms: | ACL, ATPCL, CLATP,CLATP|ATPCL | Locus: | 17q12-q21 in Homo sapiens |
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| General Comment | NCBI Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] | ||||
| General function | Enzyme | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Expression regulated by | LH | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | March 1, 2009, 6:59 a.m. | by: |
hsueh email:
home page: |
| last update: | April 16, 2009, 10:01 a.m. | by: | hsueh email: |
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