| Regulator Of G Protein Signaling 1 | OKDB#: 4040 |
| Symbols: | RGS1 | Species: | human | ||
| Synonyms: | 1R20, BL34, IER1, IR20,IMMEDIATE-EARLY RESPONSE 1, B-CELL SPECIFIC, IER1|1R20|BL34 | Locus: | 1q31 in Homo sapiens |
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| General Comment | NCBI Summary: This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq] | ||||
| General function | Intracellular signaling cascade | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian localization | Oocyte | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | March 15, 2009, 7:58 a.m. | by: |
hsueh email:
home page: |
| last update: | March 15, 2009, 7:58 a.m. | by: | hsueh email: |
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