| cathelicidin antimicrobial peptide | OKDB#: 4041 |
| Symbols: | CAMP | Species: | human | ||
| Synonyms: | LL37, CAP18, CRAMP, HSD26, CAP-18, FALL39, FALL-39,LL37, CAP18, CRAMP, HSD26, FALL39, FALL-39,PEPTIDE ANTIBIOTIC, PR-39, PORCINE, HOMOLOG OF, FALL39|CATIONIC ANTIMICROBIAL PROTEIN, 18-KD, CAP18|LL37|CRAMP, MOUSE, HOMOLOG OF, CRAMP | Locus: | 3p21.3 in Homo sapiens |
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| General Comment | NCBI Summary: This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. The encoded protein has several functions in addition to antimicrobial activity, including cell chemotaxis, immune mediator induction and inflammatory response regulation. [provided by RefSeq, Aug 2011] | ||||
| General function | Ligand | ||||
| Comment | |||||
| Cellular localization | Extracellular Matrix | ||||
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| Ovarian function | |||||
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| Ovarian localization | Oocyte, Cumulus | ||||
| Comment | Anti-Bacterial Factors Secreted From Cumulus Cells of Ovulated COCs Enhance Sperm Capacitation During In Vitro Fertilization. Shimada M et al. PROBLEM: The aim of this study was to find immune-related genes expressed in cumulus cells of ovulated cumulus oocyte complexes (COCs) and to clear the functional roles during fertilization process. METHOD OF STUDY: Ovulated COCs were collected from oviduct 16hr after the hCG injections followed by eCG priming. The cumulus cells were used for RT-PCR or western blotting study. COCs were also used for in vitro fertilization study. RESULTS: Cramp, Trf, Lyz2, S100a8, and S100a9 were expressed in cumulus cells during ovulation process. The protein levels of CRAMP or transferrin were detected in ovulated COCs and then secreted into hyaluronan-rich matrix. The high dose of these factors reduced the proliferative activity of E. coli; however, the lower levels of them significantly increased the rate of fertilization in in vitro via the induction of sperm capacitation. CONCLUSION: Cumulus-secreted anti-bacterial factors act on sperm to induce sperm capacitation. | ||||
| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | March 15, 2009, 1:23 p.m. | by: |
hsueh email:
home page: |
| last update: | Oct. 6, 2012, 3:29 p.m. | by: | hsueh email: |
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