| Adenylate Kinase 3-like 1 | OKDB#: 4095 |
| Symbols: | AK3L1 | Species: | human | ||
| Synonyms: | AK3, AK4, MGC166959,AK4, MOUSE, HOMOLOG OF, AK4|ADENYLATE KINASE 3, FORMERLY, AK3, FORMERLY | Locus: | 1p31.3 in Homo sapiens |
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| General Comment | NCBI Summary: This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq] | ||||
| General function | Intracellular signaling cascade | ||||
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| Cellular localization | Cytoplasmic, Plasma membrane | ||||
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| Ovarian localization | Oocyte, Luteal cells | ||||
| Comment | Localization of adenylate kinase 4 in mouse tissues. Miyoshi K et al. Adenylate kinase (AK) is a key enzyme in the high-energy phosphoryl transfer reaction in living cells. Of its isoforms, AK4 has a similar sequence and subcellular localization to that of AK3 in the mitochondrial matrix. However, unlike AK3, AK4 lacks the guanosine triphosphate: adenosine monophosphate phosphotransferase activity. To elucidate the physiological role of AK4, we explored the protein localization of AK4 in various mouse tissues by immunohistochemical analysis. AK4 protein was detected in the kidney, liver, brain, heart, stomach, intestine, and gonads but not in the lung and spleen. Interestingly, cell-type specific expression was evident in the brain, gastrointestinal tract, and gonads. In the cerebellum, AK4 was detected in granular cells but not in Purkinje cell bodies. In the gastrointestinal tract, AK4 was highly expressed in epithelia. In the ovary, AK4 was detected in oocytes and corpora lutea. In the testis, AK4 was detected in spermatocytes but not in spermatogonia. Our findings demonstrate that AK4 localizes uniquely in a cell-type and tissue-specific manner in mouse tissues. | ||||
| Follicle stages | Corpus luteum | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 10, 2009, 5:57 a.m. | by: |
hsueh email:
home page: |
| last update: | June 10, 2009, 6:01 a.m. | by: | hsueh email: |
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