| proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 | OKDB#: 4132 |
| Symbols: | Psmd9 | Species: | human | ||
| Synonyms: | Bridge, Bridge-1, | Locus: | 12q16 in Homo sapiens |
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| General Comment |
Bridge-1 is expressed in human granulosa cells and is involved in the activin A signaling cascade. Banz C et al. The present study investigates the expression of the coactivator Bridge-1 in the human ovary and its role in activin A signaling in the human granulosa cell line HGL-5. Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of Smad 2, 3, and 4; treatment with Bridge-1-small interfering RNA is decreasing not only the expression of Bridge-1 but also the expression of Smad2, 3, and 4 in HGL-5 cells.
NCBI Summary: interacts with E2A transcription factors; acts as a transcription coactivator; may regulate transcription of the insulin gene [RGD] |
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| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
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| created: | Sept. 29, 2009, 8:43 p.m. | by: |
hsueh email:
home page: |
| last update: | Sept. 29, 2009, 8:43 p.m. | by: | hsueh email: |
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