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HPMR

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proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 OKDB#: 4132
 Symbols: Psmd9 Species: human
 Synonyms: Bridge, Bridge-1,  Locus: 12q16 in Homo sapiens


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General Comment Bridge-1 is expressed in human granulosa cells and is involved in the activin A signaling cascade. Banz C et al. The present study investigates the expression of the coactivator Bridge-1 in the human ovary and its role in activin A signaling in the human granulosa cell line HGL-5. Expression of Bridge-1 can be stimulated by activin A, an important factor for follicle maturation, matching the increase of Smad 2, 3, and 4; treatment with Bridge-1-small interfering RNA is decreasing not only the expression of Bridge-1 but also the expression of Smad2, 3, and 4 in HGL-5 cells.

NCBI Summary: interacts with E2A transcription factors; acts as a transcription coactivator; may regulate transcription of the insulin gene [RGD]
General function
Comment
Cellular localization
Comment
Ovarian function
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Expression regulated by
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Ovarian localization
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Follicle stages
Comment
Phenotypes
Mutations 0 mutations
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Phenotypes and GWAS show phenotypes and GWAS
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created: Sept. 29, 2009, 8:43 p.m. by: hsueh   email:
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last update: Sept. 29, 2009, 8:43 p.m. by: hsueh    email:



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