| G protein-coupled receptor 137B | OKDB#: 4224 |
| Symbols: | GPR137B | Species: | human | ||
| Synonyms: | TM7SF1,TM7SF1,TRANSMEMBRANE 7 SUPERFAMILY, MEMBER 1, LONG, INCLUDED, TM7SF1L, INCLUDED|TRANSMEMBRANE 7 SUPERFAMILY, MEMBER 1, INTERMEDIATE, INCLUDED, TM7SF1I, INCLUDED|TRANSMEMBRANE 7 SUPERFAMILY, MEMBER 1, SHORT, INCLUDED, TM7SF1S, INCLUDED | Locus: | 1q42-q43 in Homo sapiens | HPMR |
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| General Comment | |||||
| General function | Receptor | ||||
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| Cellular localization | Plasma membrane | ||||
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| Ovarian function | Early embryo development | ||||
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| Expression regulated by | |||||
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| Ovarian localization | Oocyte, Cumulus | ||||
| Comment | Identification of a novel gene set in human cumulus cells predictive of an oocyte's pregnancy potential. Iager AE et al. OBJECTIVE: To identify a gene expression signature in human cumulus cells (CCs) predictive of pregnancy outcome across multiple clinics, taking into account the clinic and patient variations inherent in IVF practice. DESIGN: Retrospective analysis of single human cumulus-oocyte complexes with the use of a combined microarray and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) approach. SETTING: Multiple private IVF clinics. PATIENT(S): Fifty-eight patients. Samples from 55 of underwent qRT-PCR analysis, and samples from 27 patients resulted in live birth. INTERVENTION(S): Gene expression analysis for correlation with pregnancy outcome on individual human CCs collected immediately after oocyte retrieval. Pregnancy prediction analysis used leave-one-out cross-validation with weighted voting. MAIN OUTCOME MEASURE(S): Combinatorial expression of 12 genes in 101 samples from 58 patients. RESULT(S): We found a set of 12 genes predictive of pregnancy outcome based on their expression levels in CCs. This pregnancy prediction model had an accuracy of 78%, a sensitivity of 72%, a specificity of 84%, a positive predictive value of 81%, and a negative predictive value of 76%. Receiver operating characteristic analysis found an area under the curve of 0.763 0.079, significantly greater than 0.5 (random chance prediction). CONCLUSION(S): Gene expression analysis in human CCs should be considered in identifying oocytes with a high potential to lead to pregnancy in IVF-ET. | ||||
| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Feb. 20, 2010, 5:50 p.m. | by: |
hsueh email:
home page: |
| last update: | Dec. 5, 2012, noon | by: | hsueh email: |
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