| microRNA 672 | OKDB#: 4253 |
| Symbols: | Mir672 | Species: | human | ||
| Synonyms: | Mirn672, mmu-mir-672, | Locus: | X in Homo sapiens |
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| General Comment | NCBI Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq] | |||
| General function | RNA metabolism, RNA processing | |||
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| Ovarian function | ||||
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| Expression regulated by | ||||
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| Ovarian localization | ||||
| Comment | MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing. Ahn HW et al. Small noncoding RNAs, such as microRNAs (miRNAs) are involved in diverse biological processes including organ development and tissue differentiation. Global disruption of miRNA biogenesis in Dicer knockout mice disrupts early embryogenesis and primordial germ cell formation. However, the role of miRNAs in early folliculogenesis is poorly understood. In order to identify a full transcriptome set of small RNAs expressed in the newborn ovary, we extracted small RNA fraction from mouse newborn ovary tissues and subjected it to massive parallel sequencing using the Genome Analyzer from Illumina. Massive sequencing produced 4,655,992 reads of 33 bp each representing a total of 154 Mbp of sequence data. The Pash alignment algorithm mapped 50.13% of the reads to the mouse genome. Sequence reads were clustered based on overlapping mapping coordinates and intersected with known miRNAs, snoRNAs, piRNA clusters, and repetitive genomic regions. 25.2% of the reads mapped to known miRNAs, 25.5% to genomic repeats, 3.5% to piRNAs, and 0.18% to snoRNAs. 398 known miRNA species were among the sequenced small RNAs, and 118 isomiR sequences that are not in the miRBase database. Let-7 family was the most abundantly expressed miRNA and mmu-mir-672, mmu-mir-322, mmu-mir-503 and mmu-mir-465 family are the most abundant X-linked miRNA detected. X-linked mmu-mir-503, mmu-mir-672 and mmu-mir-465 family showed preferential expression in testes and ovaries. We also identified 4 novel miRNAs that are preferentially expressed in gonads. Gonadal selective miRNAs may play important roles in ovarian development, folliculogenesis, and female fertility. | |||
| Follicle stages | ||||
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| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
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| created: | March 16, 2010, 8:08 p.m. | by: |
hsueh email:
home page: |
| last update: | March 16, 2010, 8:08 p.m. | by: | hsueh email: |
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