| DnaJ (Hsp40) homolog, subfamily C, member 2 | OKDB#: 4437 |
| Symbols: | DNAJC2 | Species: | human | ||
| Synonyms: | ZRF1, ZUO1, MPP11, MPHOSPH11, | Locus: | 7q22 in Homo sapiens |
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| General Comment |
ZF1 displaces RC1 from chromatin to increase transcription
NCBI Summary: This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq] |
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Jan. 16, 2011, 9:26 a.m. | by: |
hsueh email:
home page: |
| last update: | Jan. 16, 2011, 9:31 a.m. | by: | hsueh email: |
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