Species: human
Mutation name: None
type: None
fertility: subfertile
Comment: Assessment of paraoxonase 1, xanthine oxidase, glutathione peroxidase activities, nitric oxide and thiol levels in women with polycystic ovary syndrome. Baskol G et al. Objectives. To investigate whether there is any relation between oxidative stress and the antioxidant system in the development of polycystic ovary syndrome (PCOS) by measuring serum nitric oxide (NO) levels and xanthine oxidase (XO) activity (a generator of reactive oxygen species) and antioxidant status by measuring serum thiol levels, glutathione peroxidase (GSHPx) and paraoxonase 1 (PON1) activities. Design. Prospective case-control study. Setting. University hospital in Turkey. Population. Thirty women with polycystic ovary syndrome and 20 age and gender-matched healthy controls were included. Methods. Serum XO, PON1, GSH activity, NO and thiol levels determined by spectrophotometric methods. Main Outcome Measures. Activity of serum XO, PON1 and GSH as well as NO and thiol levels. Results. Serum XO activities were higher in women with PCOS than the controls (p<0.001). PON1 activity was lower in women with PCOS than the controls (p<0.001). No significant difference was found between NO, thiol levels and GSHPx activities of women with PCOS and the controls (p> 0.05). Serum PON1 activities were negatively correlated with serum XO activities and NO levels. Conclusion. Increased oxidant XO activity and decreased lipid antioxidant PON1 activity along with the observed negative correlation between these parameters suggests that women with PCOS are under oxidative stress and that there is XO mediated lipid peroxidation which may be related to increased atherosclerosis seen in later life in such women.