NCBI Summary:
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
General function
Ligand, Cytokine
Comment
Cellular localization
Secreted
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Ovarian function
Comment
Is IL-17 Involved in the Interaction Between Polycystic Ovary Syndrome and Gingival Inflammation? Oz?a O et al. Background:Polycystic ovarian syndrome (PCOS) is a hormonal disorder of women of reproductive age that impacts on their oral and systemic health. The aim of this study was to evaluate interleukin-17A (IL-17A), IL-17F, IL-17A/F and IL-17E (IL-25) levels in gingival crevicular fluid (GCF), saliva and serum of non-obese women with PCOS and with either a clinically healthy periodontium or gingivitis. Materials & Methods: Thirty-one women with PCOS, 30 women with PCOS and gingivitis and 12 systemically and periodontally healthy women participated in the study. Clinical periodontal measurements, body mass index (BMI) and Ferriman-Gallwey score (FGS) (a measure of hirsuitism in women) were recorded. Circulating levels of sex hormones, cortisol and insulin were also determined. Levels of IL-17 cytokines were measured by enzyme-linked immunosorbent assay (ELISA). Results: The General linear model multivariate analysis, adjusting for age or plaque index, showed that the two groups with PCOS had higher concentrations of: IL-17A, IL-17F and IL-17A/F in serum; higher levels of IL-17A and IL-17F in GCF and saliva but lower serum IL-17E than systemically healthy women. Levels of IL-17E were lowest in women with PCOS and gingivitis who also had the highest FGS. Serum IL-17A and IL-17F levels correlated positively with FGS and periodontal pocket depth (all: rho >0.33; p<0.005). Serum IL-17E showed the reverse relationship and also correlated negatively with IL-17A (rho> -0.28; p<0.05). Conclusion: IL-17 levels are altered in non-obese women with PCOS and may influence gingival inflammation. Further studies are warranted to clarify the relationship between PCOS and gingivitis.
Expression regulated by
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Ovarian localization
, Follicular Fluid
Comment
Association of IL-17 and IL-23 follicular fluid concentrations and gene expression profile in cumulus cells from infertile women at risk for ovarian hyperstimulation syndrome. Motamedzadeh L et al. (2019) This study determined the association between the levels of interleukin (IL)-17 and IL-23 in follicular fluid (FF), as well as their mRNA levels in cumulus cells from infertile women at risk for ovarian hyperstimulation syndrome (OHSS). In this case-controlled study, the control group (n = 40) was infertile women whose partners had male factor infertility, whereas the case group (n = 40) was infertile women at risk of OHSS. IL-17 and IL-23 concentrations in FF were measured using an enzyme-linked immunosorbent assay method, whereas the mRNA expression levels of IL-17 and IL-23 of cumulus cells were determined using RT-PCR. Significantly higher levels of IL-17 were seen in the case group (p = 0.04), whereas there was no significant difference in IL-23 concentrations between the two groups (p = 0.3). The mRNA levels of IL-17 and IL-23 showed no significant differences. In the case group, there was a positive significant correlation between the IL-23 concentration in FF and the oocyte maturation rates (p = 0.01). In the case group, the number of follicles, MII oocytes, immature oocytes, fertilized oocytes and number of embryos were significantly higher than the control group (p < 0.05). Our findings showed that the mRNA expressions of IL-17 and IL-23 were similar in the two groups, and IL-17 was increased in the case group.//////////////////
IL-17A concentration of seminal plasma and follicular fluid in infertile men and women with various clinical diagnoses. Sabbaghi M 2014 et al.
Seminal plasma and follicular fluid (FF) cytokine analysis are valuable tools for diagnoses and validation of therapeutic approaches for improving the chance of conception. Despite the initial discovery over a decade ago, the IL-17 family has not received much attention in the case of infertility. In this study, we analyzed the level of IL-17A in seminal plasma, follicular fluid and blood serum of infertile patients with different clinical diagnoses by Enzyme Linked Immunosorbent Assay (ELISA). The results showed that the level of IL-17A was higher in seminal plasma and blood serum of varicocele patients than the control group. The level of this cytokine was higher in follicular fluid of endometriosis, polycystic ovary syndrome (PCOS) and tubal factor patients than the control group. A similar elevation in IL-17A level was observed in blood serum of these patients. Furthermore, there was a correlation between the numbers of meiosis I (MI) oocytes and the level of blood serum and follicular fluid IL-17A in PCOS patients. Our data suggest a putative role of IL-17A in mediating these conditions and may have possible applications in the development of more effective diagnostic tools and therapeutic treatments for human reproductive disorders.
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