| protein kinase C, iota | OKDB#: 4730 |
| Symbols: | PRKCI | Species: | human | ||
| Synonyms: | PKCI, DXS1179E, nPKC-iota, | Locus: | 3q26.3 in Homo sapiens |
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| General Comment |
upstream of Hippo signaling
NCBI Summary: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008] |
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| General function | Enzyme | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | July 22, 2012, 11:33 a.m. | by: |
hsueh email:
home page: |
| last update: | July 22, 2012, 11:37 a.m. | by: | hsueh email: |
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