| membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) | OKDB#: 4769 |
| Symbols: | MPP5 | Species: | human | ||
| Synonyms: | PALS1, | Locus: | 14q23.3 in Homo sapiens |
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| General Comment |
Hippo upstream signaling gene
NCBI Summary: This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
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| General function | Enzyme | ||||
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| Cellular localization | Plasma membrane | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Sept. 5, 2012, 5:36 p.m. | by: |
Hsueh email:
home page: |
| last update: | Sept. 5, 2012, 5:38 p.m. | by: | Hsueh email: |
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