NCBI Summary:
RNF43 is a HAP95 (AKAP8L; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004 [PubMed 15492824]; Sugiura et al., 2008 [PubMed 18313049]).[supplied by OMIM, Dec 2008]
General function
Enzyme
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Cellular localization
Cytoplasmic
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Ovarian function
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Expression regulated by
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Ovarian localization
Ovarian tumor
Comment
RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary. Ryland GL et al. Mucinous carcinomas represent a distinct morphological subtype which can arise from several organ sites including the ovary, and their genetic characteristics are largely under-described. Exome sequencing of 12 primary mucinous ovarian tumours identified RNF43 as the most frequently somatically mutated novel gene, secondary to KRAS and mutated at an equal frequency with TP53 and BRAF. Further screening of RNF43 in a larger cohort of ovarian tumours identified additional mutations, with a total frequency of 2 of 22 (9%) in mucinous ovarian borderline tumours and 6 of 29 (21%) in mucinous ovarian carcinomas. Seven mutations were predicted to truncate the protein and one missense mutation was predicted to be deleterious by in silico analysis. Six tumours had allelic imbalance at the RNF43 locus with loss of the wildtype allele. The mutation spectrum strongly suggests that RNF43 is an important tumour suppressor gene in mucinous ovarian tumours, similar to its reported role in mucinous pancreatic pre-cancerous cysts. Copyright 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.