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HPMR

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DnaJ (Hsp40) homolog, subfamily C, member 15 OKDB#: 4798
 Symbols: DNAJC15 Species: human
 Synonyms: MCJ, HSD18, DNAJD1,  Locus: 13q14.1 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: Entrez Gene
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General Comment
General function
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Cellular localization
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Ovarian function Early embryo development
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Expression regulated by
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Ovarian localization Cumulus
Comment Identification of a novel gene set in human cumulus cells predictive of an oocyte's pregnancy potential. Iager AE et al. OBJECTIVE: To identify a gene expression signature in human cumulus cells (CCs) predictive of pregnancy outcome across multiple clinics, taking into account the clinic and patient variations inherent in IVF practice. DESIGN: Retrospective analysis of single human cumulus-oocyte complexes with the use of a combined microarray and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) approach. SETTING: Multiple private IVF clinics. PATIENT(S): Fifty-eight patients. Samples from 55 of underwent qRT-PCR analysis, and samples from 27 patients resulted in live birth. INTERVENTION(S): Gene expression analysis for correlation with pregnancy outcome on individual human CCs collected immediately after oocyte retrieval. Pregnancy prediction analysis used leave-one-out cross-validation with weighted voting. MAIN OUTCOME MEASURE(S): Combinatorial expression of 12 genes in 101 samples from 58 patients. RESULT(S): We found a set of 12 genes predictive of pregnancy outcome based on their expression levels in CCs. This pregnancy prediction model had an accuracy of 78%, a sensitivity of 72%, a specificity of 84%, a positive predictive value of 81%, and a negative predictive value of 76%. Receiver operating characteristic analysis found an area under the curve of 0.763 0.079, significantly greater than 0.5 (random chance prediction). CONCLUSION(S): Gene expression analysis in human CCs should be considered in identifying oocytes with a high potential to lead to pregnancy in IVF-ET.
Follicle stages
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Phenotypes
Mutations 0 mutations
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Phenotypes and GWAS show phenotypes and GWAS
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created: Dec. 5, 2012, 12:09 p.m. by: hsueh   email:
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last update: Dec. 5, 2012, 12:10 p.m. by: hsueh    email:



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