| antigen identified by monoclonal antibodies 1D12, 2F7 | OKDB#: 4813 |
| Symbols: | MER2 | Species: | human | ||
| Synonyms: | Locus: | 11p15.5 in Homo sapiens |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
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Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment | NCBI Summary: DISCONTINUED: This record has been withdrawn by HGNC | ||||
| General function | Chromosome organization, DNA repair | ||||
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| Ovarian function | Oocyte maturation | ||||
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| Expression regulated by | |||||
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| Ovarian localization | Oocyte | ||||
| Comment | The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination. Acquaviva L et al. During meiosis, combinatorial associations of genetic traits arise from homologous recombination between parental chromosomes. Histone H3 lysine 4 trimethylation marks meiotic recombination hotspots in yeast and mammals, but how this ubiquitous chromatin modification relates to the initiation of double-strand breaks (DSBs) dependent on Spo11 remains unknown. Here, we show that the tethering of a PHD-containing protein, Spp1 (a component of the COMPASS complex), to recombinationally cold regions is sufficient to induce DSB formation. Furthermore, we found that Spp1 physically interacts with Mer2, a key protein of the differentiated chromosomal axis required for DSB formation. Thus, by interacting with H3K4me3 and Mer2, Spp1 promotes recruitment of potential meiotic DSB sites to the chromosomal axis, allowing Spo11 cleavage at nearby nucleosome-depleted regions. | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Dec. 26, 2012, 7:48 p.m. | by: |
donghuih email:
home page: |
| last update: | May 7, 2020, 9:59 a.m. | by: | hsueh email: |
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