Blending Hippo and WNT: Sharing Messengers and Regulation. Tsai BP et al. Two new studies reveal ways in which the Wnt pathway commandeers Hippo components for signaling. Azzolin etal. show how the Hippo transcription factor TAZ mediates Wnt signals, and Rosenbluh etal. show how -catenin and YAP1 form a kinase-regulated complex with transcription factor TBX5.
Hippo signaling
NCBI Summary:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
General function
Nucleic acid binding, DNA binding, Transcription factor