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HPMR

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neuromedin U receptor 2 OKDB#: 4835
 Symbols: NMUR2 Species: human
 Synonyms: FM4, FM-4, TGR1, NMU2R, TGR-1, NMU-R2,  Locus: 5q33.1 in Homo sapiens
HPMR


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General Comment NCBI Summary: This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Steroid metabolism
Comment Ovarian regulation of neuromedin U and its local actions in the ovary, mediated through neuromedin U receptor 2. Lin TY et al. Neuromedin U (NMU) was originally identified as an anorexigenic peptide that modulates appetite as well as energy homeostasis through the brain-gut axis. Although growing evidence has linked NMU activity with the development of female reproductive organs, no direct expression of and function for NMU in these organs has been pinpointed. Using a superovulated rat model, we found that NMU is directly expressed in the ovary, where its transcript level is tightly regulated by gonadotropins. Ovarian microdissection and immunohistochemical staining showed clearly that NMU is expressed mainly in theca/interstitial cells and to a moderate extent in granulosa cells. Primary cell studies together with reporter assays indicated the Nmu mRNA level in these cells is strongly induced via cAMP signaling, whereas this increase in expression can be reversed by the degradation message residing within its 3'-untranslated region, which recruits cis-acting mRNA degradation mechanisms, such as the gonadotropin-induced zinc finger RNA-binding protein Zfp36l1. This study also demonstrated that NMUR2, but not NMUR1, is the dominant NMU receptor in the ovary, where its expression is restricted to theca/interstitial cells. Treatment with NMU led to induction of the early-response c-Fos gene, phosphorylation of ERK1/2 and promotion of progesterone production in both developing and mature theca/interstitial cells. Taken as a whole, this study demonstrates that NMU and NMUR2 compose a novel autocrine system in theca/interstitial cells in which the intensity of signaling is tightly controlled by gonadotropins.
Expression regulated by
Comment
Ovarian localization Theca
Comment
Follicle stages Antral
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Feb. 26, 2013, 12:41 p.m. by: hsueh   email:
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last update: Feb. 26, 2013, 12:42 p.m. by: hsueh    email:



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