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Rho family GTPase 3 OKDB#: 4888
 Symbols: RND3 Species: human
 Synonyms: ARHE, Rho8, RhoE, memB,  Locus: 2q23.3 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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DNA Microarrays
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link to BioGPS
General Comment NCBI Summary: This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
General function Cytoskeleton
Comment
Cellular localization Cytoskeleton
Comment
Ovarian function
Comment
Expression regulated by LH
Comment
Ovarian localization Granulosa, Theca
Comment Research Resource: Pre-ovulatory LH surge effects on follicular theca and granulosa transcriptomes. Christenson LK et al. The molecular mechanisms that regulate the pivotal transformation processes observed in the follicular wall following the pre-ovulatory LH-surge, are still not established, particularly for cells of the thecal layer. To elucidate thecal and granulosa cell type-specific biological functions and signaling pathways, large dominant bovine follicles were collected before and 21 hrs after an exogenous GnRH induced LH surge. Antral granulosa (aGC; aspirated by follicular puncture) and membrane-associated granulosa (mGC; scraped from the follicular wall) were compared to thecal cell expression profiles determined by mRNA microarrays. Of the ~11,000 total genes expressed in the peri-ovulatory follicle, only 2% of thecal versus 25% of the granulosa genes changed in response to the LH surge. The majority of the 203 LH-regulated thecal genes were also LH regulated in granulosa cells, leaving a total of 57 genes as LH-regulated theca cell specific genes. Of the 57 thecal specific LH-regulated genes, 74% were downregulated including CYP17A1 and NR5A1, while most other genes are being identified for the first time within theca. Many of the newly identified upregulated thecal genes (e.g., PTX3, RND3, PPP4R4) were also upregulated in granulosa. Minimal expression differences were observed between aGC and mGC, however, transcripts encoding extracellular proteins (NID2) and matrix modulators (ADAMTS1, SASH1) predominated these differences. We also identified large numbers of unknown LH-regulated granulosa cell genes and discuss their putative roles in ovarian function. This Research Resource provides an easy to access global evaluation of LH regulation in thecal and granulosa cells that implicate numerous molecular pathways hereto unknown within the follicle.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
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created: June 3, 2013, 12:09 p.m. by: hsueh   email:
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last update: June 3, 2013, 12:10 p.m. by: hsueh    email:



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