| UPF1 regulator of nonsense transcripts homolog (yeast) | OKDB#: 4998 |
| Symbols: | UPF1 | Species: | human | ||
| Synonyms: | HUPF1, NORF1, RENT1, smg-2, pNORF1, | Locus: | 19p13.2-p13.11 in Homo sapiens |
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| General Comment | NCBI Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008] | ||||
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| Ovarian localization | Oocyte, Granulosa | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | March 31, 2014, 6:43 a.m. | by: |
Hsueh email:
home page: |
| last update: | March 31, 2014, 6:45 a.m. | by: | Hsueh email: |
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