| histone deacetylase 5 | OKDB#: 5034 |
| Symbols: | HDAC5 | Species: | human | ||
| Synonyms: | HD5, NY-CO-9, | Locus: | 17q21 in Homo sapiens |
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| General Comment | NCBI Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 6, 2014, 7:25 a.m. | by: |
Hsueh email:
home page: |
| last update: | June 6, 2014, 7:25 a.m. | by: | Hsueh email: |
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