| microRNA 139 | OKDB#: 5070 |
| Symbols: | MIR139 | Species: | human | ||
| Synonyms: | MIRN139, MIR139-3p, | Locus: | 11q13.4 in Homo sapiens |
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| General Comment | NCBI Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] | ||||
| General function | RNA processing | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | |||||
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| Ovarian localization | Granulosa | ||||
| Comment | Hyaluronic Acid Promotes the Expression of Progesterone Receptor Membrane Component 1 via Epigenetic Silencing of miR-139-5p in Granulosa Cells. Zhao G 2014 et al. Primary ovarian insufficiency (POI) is a serious reproductive dysfunction with the follicle pool reduced and depleted. Abnormal apoptosis of ovarian granulosa cells (GCs) is believed to result in follicle loss. Progesterone receptor membrane component (PGRMC) 1, critical for the GC survival, was reported to reduce in POI patients, but the mechanism is unknown. Here we found that PGRMC1 expression was correlated with hyaluronic acid (HA) level in POI patients. HA up-regulated PGRMC1 expression in GCs via suppression of miR-139-5p, which was proved to target PGRMC1 by Western blotting and luciferase reporter assays. Consistent with these findings, miR-139-5p level was significantly increased and presented an inverse correlation with PGRMC1 in POI patients. Noticeably, HA inhibited CD44-mediated miR-139-5p expression, but had no effect on luciferase activity after insertion of miR-139 promoter into luciferase plasmid. Interestingly, miR-139-5p was significantly up-regulated in the KGN cells (GC tumor cell line) by histone deacetylase inhibitor, trichostatin A, indicating that HA down-regulated miR-139-5p expression via histone deacetylation. Taken together, we report an unrecognized mechanism of HA in the promotion of PGRMC1 expression, suggesting that HA may be a potential molecule for the prevention and treatment of POI. ///////////////////////// | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Sept. 19, 2014, 11:40 a.m. | by: |
hsueh email:
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| last update: | Sept. 19, 2014, 11:40 a.m. | by: | hsueh email: |
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