| dedicator of cytokinesis 2 | OKDB#: 5214 |
| Symbols: | DOCK2 | Species: | human | ||
| Synonyms: | Locus: | 5q35.1 in Homo sapiens |
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| General Comment | NCBI Summary: The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011] | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 19, 2015, 1:27 p.m. | by: |
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| last update: | June 19, 2015, 1:28 p.m. | by: | hsueh email: |
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