| RAB27A, member RAS oncogene family | OKDB#: 5342 |
| Symbols: | RAB27A | Species: | human | ||
| Synonyms: | GS2, RAM, RAB27, HsT18676 | Locus: | 15q21.3 in Homo sapiens |
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| General Comment | NCBI Summary: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] | ||||
| General function | Intracellular signaling cascade | ||||
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| Cellular localization | Plasma membrane | ||||
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| Ovarian function | Oocyte maturation | ||||
| Comment | Rab3A, Rab27A, and Rab35 regulate different events during mouse oocyte meiotic maturation and activation. Wang HH et al. (2016) Rab family members play important roles in membrane trafficking, cell growth, and differentiation. Almost all components of the cell endomembrane system, the nucleus, and the plasma membrane are closely related to RAB proteins. In this study, we investigated the distribution and functions of three members of the Rab family, Rab3A, Rab27A, and Rab35, in mouse oocyte meiotic maturation and activation. The three Rab family members showed different localization patterns in oocytes. Microinjection of siRNA, antibody injection, or inhibitor treatment showed that (1) Rab3A regulates peripheral spindle and cortical granule (CG) migration, polarity establishment, and asymmetric division; (2) Rab27A regulates CG exocytosis following MII-stage oocyte activation; and (3) Rab35 plays an important role in spindle organization and morphology maintenance, and thus meiotic nuclear maturation. These results show that Rab proteins play important roles in mouse oocyte meiotic maturation and activation and that different members exert different distinct functions.////////////////// | ||||
| Expression regulated by | |||||
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| Ovarian localization | Oocyte | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Jan. 27, 2016, 11:04 a.m. | by: |
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| last update: | Jan. 27, 2016, 11:05 a.m. | by: | hsueh email: |
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