| lysyl oxidase like 2 | OKDB#: 5349 |
| Symbols: | LOXL2 | Species: | human | ||
| Synonyms: | LOR2, WS9-14 | Locus: | 8p21.3 in Homo sapiens |
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Entrez Gene
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| General Comment | NCBI Summary: This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] | ||||
| General function | Enzyme | ||||
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| Cellular localization | Secreted, Cytoplasmic | ||||
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| Ovarian localization | Oocyte | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Feb. 9, 2016, 3:13 p.m. | by: |
system email:
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| last update: | Feb. 9, 2016, 3:14 p.m. | by: | hsueh email: |
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