DNA Microarrays
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Select Experiment :
Oocyte and Early Embryos
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OocyteDevelopment
PreEmbryoHuman
PreEmbryoMouse
PreimplantMmEmbryo
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Follicle_Maturation_and_Ovulation_POnly
Castrillon_Ovary_Set
Castrillon_Soma_Set
EmbryonicOvary
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Mm_Testis_Development
NormEndometrium
PituitaryAdenoma
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Preimplantation Mouse Embryo
Description :
Fields :
General Comment
NCBI Summary:
This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
General function
Cytoskeleton organization
Comment
Cellular localization
Comment
Ovarian function
Oocyte maturation, Early embryo development
, First polar body extrusion
Comment
Loss of function of KIF1B impairs oocyte meiotic maturation and early embryonic development in mice. Kong XW et al. (2016) Kinesin family member 1B (KIF1B) is an important microtubule-dependent monomeric motor in mammals, although little is known about its role in meiosis. We profiled KIF1B expression and localization during oocyte maturation and early embryonic development in mice, revealing a dynamic pattern throughout meiotic progression. Depletion or inhibition of KIF1B leads to abnormal polar body extrusion, disordered spindle dynamics, defects in chromosome congression, increased aneuploidy, and impaired embryonic development. Further, KIF1B depletion affects the distribution of mitochondria and abundance of ATP. Taken together, our study demonstrates that mouse KIF1B is important for spindle assembly, chromosome congression, and mitochondrial distribution during oocyte maturation and early embryonic development. Mol. Reprod. Dev. 9999: 1-14, 2016. © 2016 Wiley Periodicals, Inc.//////////////////
Expression regulated by
Comment
Ovarian localization
Oocyte
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Follicle stages
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Phenotypes
Mutations
0 mutations
Genomic Region
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Phenotypes and GWAS
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