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Ovarian Kaleidoscope Database (OKdb)

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kinesin family member 1B OKDB#: 5417
 Symbols: KIF1B Species: human
 Synonyms: KLP, CMT2, CMT2A, CMT2A1, HMSNII, NBLST1  Locus: 1p36.22 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment NCBI Summary: This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
General function Cytoskeleton organization
Comment
Cellular localization
Comment
Ovarian function Oocyte maturation, Early embryo development , First polar body extrusion
Comment Loss of function of KIF1B impairs oocyte meiotic maturation and early embryonic development in mice. Kong XW et al. (2016) Kinesin family member 1B (KIF1B) is an important microtubule-dependent monomeric motor in mammals, although little is known about its role in meiosis. We profiled KIF1B expression and localization during oocyte maturation and early embryonic development in mice, revealing a dynamic pattern throughout meiotic progression. Depletion or inhibition of KIF1B leads to abnormal polar body extrusion, disordered spindle dynamics, defects in chromosome congression, increased aneuploidy, and impaired embryonic development. Further, KIF1B depletion affects the distribution of mitochondria and abundance of ATP. Taken together, our study demonstrates that mouse KIF1B is important for spindle assembly, chromosome congression, and mitochondrial distribution during oocyte maturation and early embryonic development. Mol. Reprod. Dev. 9999: 1-14, 2016. © 2016 Wiley Periodicals, Inc.//////////////////
Expression regulated by
Comment
Ovarian localization Oocyte
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Nov. 16, 2016, 9:55 a.m. by: system   email:
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last update: Nov. 16, 2016, 9:58 a.m. by: hsueh    email:



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