| ubiquitin C | OKDB#: 549 |
| Symbols: | UBC | Species: | rat | ||
| Synonyms: | HMG20 | Locus: | 12q24.3 in Homo sapiens |
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| General Comment |
Ubiquitin may be evolution's most conserved protein, presumably because of its role in several important cellular processes.
The protein deposits in neurofibrillary tangles, neuritic plaques, and neuropil threads in the cerebral cortex of patients with Alzheimer disease.
Three types of ubiquitin have been identified: A, B (OMIM 191339), and C. The ubiquitin C (UBC) mRNA corresponds to a 9-coding-unit polyubiquitin gene.
NCBI Summary: This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010] |
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| Ovarian function | Unknown, Oogenesis, Oocyte maturation | ||||
| Comment | Gene whose expression is detected by cDNA array hybridization: housekeeping genes Rozenn Dalbis-Tran and Pascal Mermilloda | ||||
| Expression regulated by | |||||
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| Ovarian localization | |||||
| Comment | This gene was found in a rat ovarian cDNA library (Unigene) | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Jan. 31, 2000, midnight | by: |
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| last update: | Feb. 3, 2016, 11:45 a.m. | by: | hsueh email: |
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