| zinc finger E-box binding homeobox 2 | OKDB#: 5589 |
| Symbols: | ZEB2 | Species: | human | ||
| Synonyms: | SIP1, SIP-1, ZFHX1B, HSPC082, SMADIP1 | Locus: | 2q22.3 in Homo sapiens |
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| General Comment | NCBI Summary: The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010] | ||||
| General function | DNA binding, Transcription factor | ||||
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| Cellular localization | Nuclear | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | Granulosa | ||||
| Comment | Transcriptome Landscape of Human Folliculogenesis Reveals Oocyte and Granulosa Cell Interactions. Zhang Y et al. (2018) The dynamic transcriptional regulation and interactions of human germlines and surrounding somatic cells during folliculogenesis remain unknown. Using RNA sequencing (RNA-seq) analysis of human oocytes and corresponding granulosa cells (GCs) spanning five follicular stages, we revealed unique features in transcriptional machinery, transcription factor networks, and reciprocal interactions in human oocytes and GCs that displayed developmental-stage-specific expression patterns. Notably, we identified specific gene signatures of two cell types in particular developmental stage that may reflect developmental competency and ovarian reserve. Additionally, we uncovered key pathways that may concert germline-somatic interactions and drive the transition of primordial-to-primary follicle, which represents follicle activation. Thus, our work provides key insights into the crucial features of the transcriptional regulation in the stepwise folliculogenesis and offers important clues for improving follicle recruitment in vivo and restoring fully competent oocytes in vitro.////////////////// Most variable genes that contributed to PC1 in GCs were ZEB2, CD44, HSPG2, KDSR, and SRRM3, with ZEB2 and CD44 as the two top variable genes (Figure 1F). | ||||
| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Nov. 27, 2018, 10:56 a.m. | by: |
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| last update: | Nov. 27, 2018, 10:57 a.m. | by: | hsueh email: |
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