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HPMR

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NLR family, pyrin domain containing 4F OKDB#: 5654
 Symbols: Nlrp4f Species: mouse
 Synonyms: C86045, Nalp4f, Nalp-kappa, C330026N02Rik  Locus: 13 in Homo sapiens


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General Comment
General function
Comment
Cellular localization
Comment
Ovarian function Oocyte maturation, Early embryo development
Comment The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution. Qin D et al. (2019) In mammalian oocytes and embryos, the subcortical maternal complex (SCMC) and cytoplasmic lattices (CPLs) are two closely related structures. Their detailed compositions and functions remain largely unclear. Here, we characterized Nlrp4f as a novel component associated with the SCMC and CPLs. Disruption of maternal Nlrp4f leads to decreased fecundity and delayed preimplantation development in the mouse. Lack of Nlrp4f affects organelle distribution in mouse oocytes and early embryos. Depletion of Nlrp4f disrupts CPL formation but does not affect the interactions of other SCMC proteins. Interestingly, the loss of Filia or Tle6, two other SCMC proteins, also disrupts CPL formation in mouse oocytes. Thus, the absence of CPLs and aberrant distribution of organelles in the oocytes disrupted the examined SCMC genes, including previously reported Zbed3, Mater, Floped and Padi6, indicate that the SCMC is required for CPL formation and organelle distribution. Consistent with the SCMC's role in CPL formation, the SCMC forms before CPLs during oogenesis. Together, our results suggest that SCMC protein Nlrp4f is involved in CPL formation and organelle distribution in mouse oocytes.//////////////////
Expression regulated by
Comment
Ovarian localization Oocyte
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Oct. 3, 2019, 9:54 a.m. by: system   email:
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last update: Oct. 3, 2019, 9:56 a.m. by: hsueh    email:



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