| spen family transcriptional repressor | OKDB#: 5714 |
| Symbols: | SPEN | Species: | human | ||
| Synonyms: | MINT, SHARP, RBM15C, HIAA0929 | Locus: | 1p36.21-p36.13 in Homo sapiens |
|
For retrieval of Nucleotide and Amino Acid sequences please go to:
OMIM
Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment |
Writing in Nature, Dossin et al.2 report a stunning series of experiments that reveal how Xist silences genes by partnering with a protein called SPEN.
NCBI Summary: This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008] |
||||
| General function | DNA binding | ||||
| Comment | |||||
| Cellular localization | Nuclear | ||||
| Comment | |||||
| Ovarian function | |||||
| Comment | |||||
| Expression regulated by | |||||
| Comment | |||||
| Ovarian localization | Oocyte, Granulosa | ||||
| Comment | |||||
| Follicle stages | |||||
| Comment | |||||
| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
|
| created: | Feb. 20, 2020, 2:15 p.m. | by: |
system email:
home page: |
| last update: | Feb. 20, 2020, 2:17 p.m. | by: | hsueh email: |
Click here to return to gene search form