| 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | OKDB#: 5721 |
| Symbols: | PFKFB1 | Species: | human | ||
| Synonyms: | F6PK, HL2K, PFRX | Locus: | Xp11.21 in Homo sapiens |
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| General Comment | NCBI Summary: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012] | ||||
| General function | Enzyme | ||||
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| Ovarian localization | Oocyte | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Feb. 26, 2020, 4:24 p.m. | by: |
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| last update: | Feb. 27, 2020, 10:35 a.m. | by: | hsueh email: |
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