| sestrin 1 | OKDB#: 5722 |
| Symbols: | SESN1 | Species: | human | ||
| Synonyms: | PA26, SEST1 | Locus: | 6q21 in Homo sapiens |
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| General Comment | NCBI Summary: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] | ||||
| General function | Intracellular signaling cascade | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | Early embryo development | ||||
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| Expression regulated by | LH | ||||
| Comment | LH suppression | ||||
| Ovarian localization | Cumulus, Granulosa | ||||
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| Follicle stages | |||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | March 5, 2020, 11:04 a.m. | by: |
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| last update: | March 5, 2020, 11:08 a.m. | by: | hsueh email: |
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