| nuclear transcription factor Y subunit alpha | OKDB#: 5747 |
| Symbols: | NFYA | Species: | human | ||
| Synonyms: | HAP2, CBF-A, CBF-B, NF-YA | Locus: | 6p21.1 in Homo sapiens |
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| General Comment | NCBI Summary: The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008] | ||||
| General function | Transcription factor | ||||
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| Cellular localization | Nuclear | ||||
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| Ovarian function | Early embryo development | ||||
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| Ovarian localization | Oocyte | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | March 27, 2020, 3:49 p.m. | by: |
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| last update: | March 27, 2020, 3:50 p.m. | by: | hsueh email: |
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