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Ovarian Kaleidoscope Database (OKdb)

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HPMR

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176557

cytosolic arginine sensor for mTORC1 subunit 1 OKDB#: 5862
 Symbols: CASTOR1 Species: human
 Synonyms: GATSL3  Locus: 22q12.2 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment
General function
Comment
Cellular localization
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Ovarian function
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Expression regulated by
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Ovarian localization Oocyte
Comment Age-related differences in the translational landscape of mammalian oocytes. Del Llano E et al. (2020) Increasing maternal age in mammals is associated with poorer oocyte quality, involving higher aneuploidy rates and decreased developmental competence. Prior to resumption of meiosis, fully developed mammalian oocytes become transcriptionally silent until the onset of zygotic genome activation. Therefore, meiotic progression and early embryogenesis are driven largely by translational utilization of previously synthesized mRNAs. We report that genome-wide translatome profiling reveals considerable numbers of transcripts that are differentially translated in oocytes obtained from aged compared to young females. Additionally, we show that a number of aberrantly translated mRNAs in oocytes from aged females are associated with cell cycle. Indeed, we demonstrate that four specific maternal age-related transcripts (Sgk1, Castor1, Aire and Eg5) with differential translation rates encode factors that are associated with the newly forming meiotic spindle. Moreover, we report substantial defects in chromosome alignment and cytokinesis in the oocytes of young females, in which candidate CASTOR1 and SGK1 protein levels or activity are experimentally altered. Our findings indicate that improper translation of specific proteins at the onset of meiosis contributes to increased chromosome segregation problems associated with female ageing.//////////////////
Follicle stages
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Phenotypes
Mutations 0 mutations
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Phenotypes and GWAS show phenotypes and GWAS
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created: Sept. 23, 2020, 2:50 p.m. by: system   email:
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last update: Sept. 23, 2020, 2:51 p.m. by: hsueh    email:



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